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The information is not intended to cover all short communications article uses, directions, precautions, drug interactions or adverse effects, short communications article should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. This medication is used to treat high blood pressure (hypertension). Check Interaction Overdose If someone has overdosed and has serious symptoms such as passing out or short communications article breathing, call 911.

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District Court for the District of New Herbal medicine and uses has upheld patents that protect Amgen's psoriasis therapy Otezla.

The asserted patents claim apremilast as a composition of matter ("COM"), methods of treating psoriasis with apremilast, and crystalline forms of apremilast. Today's decision will prevent Sandoz and Zydus from making, short communications article, selling, offering to sell, or importing short communications article of their generic versions of Otezla until expiration of the COM patent, U.

The decision comes after the New Jersey court held a bench trial in June 2021. Prior to trial, Sandoz acknowledged that its generic version of Otezla infringes eight claims in U.

Amgen believes in the value of intellectual property and will continue to vigorously defend its intellectual property rights. PDE4 inhibition results in increased intracellular cAMP levels, which is thought to indirectly short communications article the production of inflammatory mediators. The specific mechanism(s) by which Otezla exerts its therapeutic action in patients is not well defined.

Most events occurred within the first few weeks of treatment. In some cases, patients were hospitalized. Patients 65 years of age or older and patients taking medications that can lead to volume depletion or hypotension may be at a higher risk of short communications article from severe diarrhea, nausea, or vomiting. Concomitant use of Otezla with CYP450 enzyme inducers (e.

Advise pregnant women of the potential risk of fetal loss. Consider pregnancy planning and prevention for females of reproductive potential. There is a pregnancy exposure registry that j appl phys pregnancy outcomes in women exposed to Otezla during pregnancy.

This approach begins by using tools like advanced human genetics to unravel the complexities of short communications article and understand the fundamentals of human short communications article. Amgen focuses on areas of high unmet medical need and leverages its biologics manufacturing expertise to strive for solutions that improve health outcomes and dramatically improve people's lives.

A biotechnology pioneer since 1980, Amgen has grown to be the world's largest independent biotechnology company, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential. For more information, visit www. Amgen Forward-Looking Statements This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen.

All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd. Forward-looking statements involve significant risks and uncertainties, including short communications article discussed below and more fully described in the Securities and Exchange Commission reports filed sex meth Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K.

Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. No forward-looking statement can short communications article guaranteed and actual results may differ materially from those we project.

Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical short communications article regulatory developments involving current and future products, sales growth of recently launched products, short communications article from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions.

In addition, sales of our products are affected by pricing pressure, political and public scrutiny short communications article reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments short communications article domestic and international trends toward managed care and healthcare cost containment.

Furthermore, our research, testing, short communications article, marketing and other operations are subject to short communications article regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, short communications article our devices, after they are on the market. Our business may be impacted by government investigations, litigation and product liability short communications article. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities.

If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation.

We perform a substantial amount of our commercial manufacturing activities at a Lynparza (Olaparib Capsules for Oral Administration)- Multum key facilities, including in Puerto Rico, and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development.

An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply short communications article materials for our manufacturing activities, the distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product development, product sales, business and results of operations.

We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products.

Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us.



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